Clinical & Translational Fungal Research - Working Group (CTFR-WG)

About the Working Group

Invasive fungal infections are an increasing threat for immunocompromised individuals and associated with devastating morbidity and mortality. Clinicians and Researchers at UC San Diego have come together and founded a multidisciplinary working group (Clinical and Translational Fungal Research - Working Group). The CTFR-WG is dedicated to advancing the understanding, diagnostics and management of invasive fungal infections. In 2018, the working group completed two studies on point-of-care diagnosis of invasive aspergillosis, and on impact of combination antifungal therapy on survival in rare mold infections, and was very active in disseminating their research findings in a total of 8 Pub Med listed publications.

Ongoing Projects

• Aspergillus and other Rare Mold Infections at UC San Diego Health (IRB #181119; PI Jenks)
• Novel Diagnostic Approaches for Invasive Pulmonary Aspergillosis (IRB #171104; PI Hoenigl)
• FungiScope Global Emerging Fungal Infections registry (IRB #171105; PI Hoenigl)
• High Resolution Melt for Rapid Diagnosis of Invasive Mold Infection in Immunosuppressed Patients. (NIH UL1TR00442)

Clinical Trials

• SCY-078-206: Study to Evaluate the Safety and Efficacy of the Combination Therapy of Ibrexafungerp (SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)
• F901318: An open-label single-arm Phase IIb study of F901318 as treatment of invasive fungal infections due to Lomentospora prolificans, Scedosporium spp., Aspergillus spp., and other resistant fungi in patients lacking suitable alternative treatment options.